پلی مورفیسم ژن TGF-β1 در موقعیت -800 G/Aو بیماری لوپوس اریتماتوزیس

Introduction: Systemic lupus erythematosus (SLE) is a chronic systemic inflammatory autoimmune disease characterized by a breakdown of self-tolerance. Transforming growth factor-&beta;1 is a cytokine produced by both immune and non immune cells, and it has a wide operating range. human TGF-&beta;1 gene is located on chromosome 19q13 . The aim of this study was investigating the TGF-&beta;1 Gene Polymorphism at Position -800G /A and Systemic Lupus Erythematosus the possible difference in two promoter polymorphisms of the transforming growth factor-&beta;1 (TGF-&beta;1) gene (-800G / A, -509C / T). Methods: In this case - control study, a total of 150 patients with SLE and 150 healthy subjects were examined. DNA was extracted by saluting out method and Single nucleotide Polymorphisms of the TGF-&beta;1gene were analyzed by the PCR-RFLP method and the .Data were compared in both groups by using Pearson&rsquo;s chi-square and Hardy-weinberg equilibrium test. Results: There was a statistically significant difference in AA genotype and A allele frequency distributions between SLE patients and the control group for the -800G / A polymorphism of the TGF-&beta;1 gene (P < 0.05). At position -509, there was no statically significant difference in genotype and allele frequency between the patients and the control subjects. Conclusion : The results of our study indicate that TGF-&beta;1 gene promoter polymorphisms at positions -800 G/A maybe discuss susceptibility to SLE in southern Iranian patients.